General Information

  • ID:  hor002546
  • Uniprot ID:  A0A6I8TEZ7
  • Protein name:  NPLP-1-2
  • Gene name:  5565029
  • Organism:  Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Stegomyia (subgenus), Aedes (genus), Aedini (tribe), Culicinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  NLGSLARAGLLRTPSTDYL
  • Length:  19
  • Propeptide:  MGNFKMLLPPKLFLRILMLLFLIVHDASSQYTDGNRRLKPCELESLLRDLTYPEEGYEMHAAALRNQLRHILEREPTDGAYQSLDEYGSYENTGPYEDKRSYRSLLRDGATFGKRNLGSLARAGLLRTPSTDYLKRSIATLAKNGQLPASREPDSEEAASAGGWNDEKRNLASARASGYMLNGKRNIASLARKYELPGKRNIQSLLRTGMLPSIAPKRNMQSLARDNSLPHFAGAAAQESKRNIQTLVRDWNLPRQQSMAADNEKRNIQSLKNAQGQGGGSSSGGRKKRELYYDDETLDDSAPEILEPVYQSSPLDYEELMEAMNEAYTPYYNSPADNHLEQKRYLGSLARAGHLHRYHRFYKRAPMGSFDGLYGNDDDDDNGTGSDNYEGEDRHKRKHASKDVLDDDNDDDDDNDEDYEPRSSVALHIPQKRHLGSIIRSGWMPSFRPSRTTGRFSRSGRARSSFTPNPSDYDNLSPAFVDDATALATAADFEQHQQQQQHPLPSAAGELPVYSPRGVLRHPELPHYTGAAFGNRPRMYAGGLPEEYLDSSSETSARPSNPFYTEDEFRCAARLRKLLYYLKKQYYLDNKYIQSVYGRNPVRY
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A6I8TEZ7-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002546_AF2.pdbhor002546_ESM.pdb

Physical Information

Mass: 233955 Formula: C88H148N26O28
Absent amino acids: CEFHIKMQVW Common amino acids: L
pI: 9.35 Basic residues: 2
Polar residues: 8 Hydrophobic residues: 7
Hydrophobicity: -0.53 Boman Index: -2718
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 113.16
Instability Index: 2974.74 Extinction Coefficient cystines: 1490
Absorbance 280nm: 82.78

Literature

  • PubMed ID:  20163154
  • Title:  Neuropeptidomics of the Mosquito Aedes Aegypti